Author Archives: Stephen
Facebook gives you cancer and infantilises the population. Ahem.
“There is no evidence because it would be hard to prove…” Aduh.
BadScience hero Ben Goldacre and Jeremy Paxman take on Baroness Greenfield, The Daily Mail (always a good target) and Aric Sigman in this interview from Newsnight. For a bit of background this is all a response to this story from the Daily Mail: http://www.dailymail.co.uk/health/article-1149207/How-using-Facebook-raise-risk-cancer.html
If you’re in my class, the page you need to comment on is here.
The Daily Mail reports Sigman is claiming (without any real evidence) that time on the computer takes you away from real people. This makes you isolated and lonely and means you are not producing the right hormones and your genes will act up – potentially leading to cancer, immune problems and impaired mental function. That’s a far reach for a newspaper article to be making, but these kind of shock headlines sell papers, or get more traffic on their website.
In this debate we see the importance of peer-reviewed research before making public claims. We see that correlation does not necessarily imply causality and we see that poor reporting of sensitive issues can lead to gross misunderstandings. If we remember, the Daily Mail was central in the reporting of the MMR vaccine scare.
When you watch this interview and read the article, can you think of responses to these questions?
– Are there parts of Sigman and Greenfield’s claims that might sound plausible?
– What kind of evidence would you want to see to support these claims?
– What is the significance of Goldacre’s comment “… you can make anything look dangerous if you are selective in which evidence you quote” ?
– Sigman makes a comment “The paper weas supposed to be a one-sided provocative feature article for The Biologist to make people think more carefully about where society is going.” How does he feel about the media attention that his words have attracted outside this publication?
– Central to Sigman’s claims were that internet use increases social isolation. He had no peer-reviewed work after 1998 to support this, yet Goldacre pointed out all these references that suggest otherwise.
– Sigman tries to re-state ‘social networking’ as a phrase meant for real-life interactions between people rather than internet-based interactions. How has his interpretation of the term led to confusion in the wider public? Who do you think is responsible for this confusion and how could it be rectified?
– Sigman tries to distance himself from the headlines and the conjectures of Greenfield and returns to his concern that internet use is having a direct and negative impact ont the lives of children. Take this opportunity to discuss the benefits and potential negative impacts of the internet with regard to childhood use.
– Goldacre makes a comment that it woudl be bad for research to prioritse what research is done based on the headlines in the newspapers. Do you agree/ disagree? Why?
– How do you think the precautionary principle might relate to the decisions parents make based on this issue?
How would you like to see this story develop? What further research would convince you of the harms or otherwise this debate?
The Kidney
Last topic for the HL Students!
The Kidney is great – it filters our blood, makes urine and ties together so many aspects of the course – cells, membrane transport, osmosis, chemistry of life, hormonal control. We can look at how it is similar to and different from the liver and how its structure reflects its function. I love the kidney.
Here’s the presentation, with some data-y questions at the end.
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More resources here:
Best kidney animation ever from biologymad.com
Quick guide to thekidney from kidneypatientguide.org.uk
Complete tutorial from Sumanas
Bilingual (Chinese and English) guide to the kidney, with rave tunes from hkedcity.net
More Loop of Henle action from the University of Colorado
Hormonal control of ADH from McGraw Hill
Diabetes recap from MedMovie
Kidney quiz from ZeroBio
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Want to see a kidney stone?
Find out more about kidney stones here.
Enzymes (Core and AHL & C2)
Covering the core and AHL/ SL Option C content, here is a rundown of enzymes, from active sites to end-product inhibition. Again, there are lots of animation resources out there, many of which are used in the presentation – click on the shadowed images to go there.
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Check out this article on the potential use of an enzyme in second-generation biofuels.
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Enzyme Basics:
What is an enzyme? from Northland (the best one – including inhibitors, pathways and feedback inhibition)
How enzymes work from McGraw Hill
Enzyme basics from KScience.co.uk
A full collection of savable enzyme animations from Husam Medical
And John Giannini’s Enzyme collection is nice and clear.
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Enzyme activity and kinetics
Nice virtual lab from KScience.co.uk
Enzyme kinetics from Wiley Interscience
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Denaturation:
Protein denaturation from McGraw Hill
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Inhibition
Complete tutorial from Wiley Interscience
What is an enzyme? from Northland
Feedback (end product) inhibition from McGraw Hill
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And here’s a quick run down on YouTube:
Protein Synthesis: Transcription and Translation (2009)
This is a re-post for the class of 2009 to revise and the 2010 group to catch on the first time… As always, click on the shadowed images for a link to an animation, or visit the links posted below.
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Core (for everyone):
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Additional Higher Level:
Click4Biology page: Transcription – Translation
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Further resources:
There are many decent Flash animations and the like on the internet, but the majority cannot be embedded. Below this YouTube video, there are some direct links to resources, some of which can be easily saved.
Learn.Genetics @ Utah
Transcribe and Translate (good, basic, interactive)
How do fireflies glow? (puts it in context)
University of Nebraska:
Protein Synthesis overview (Good enough for SL)
Transcription Details (fits DP Bio HL very well)
Translation Details (fits DP Bio HL very well)
John Kyrk: (visit the parent site at www.johnkyrk.com – excellent)
Transcription (fits DP Bio HL very well)
Translation (fits DP Bio HL very well)
St. Olaf College
Transcription (clear and simple)
Translation (clear and simple)
EDIT: Two more animations (from mrhardy’s wikispace, original source unknown)
WH Freeman
RNA Splicing tutorial (HL only)
Bio3400
Translation with a genetic code dictionary (shows position in the ribosome)
Some more in-depth animations (newly added):
Translation from Wiley Interscience
Translation from LSU Medschool
Translation from The Chinese University in Hong Kong
Protein targeting from Rockefeller University
DNA Replication (Core and AHL)
This topic is well-resourced on the internet – almost too well! Standard level students need to know the bare basics, which equates to the process of replication of the leading strand for the HL students. Here is the presentation, with some good links to follow:
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DNA Replication animations:
St. Olaf’s nice and clear animation.
Another clear one from Wiley.
Nicely illustrated one from Harvard.
John Kyrk’s complicated molecular animation.
The Meselsohn Stahl experiment from Sumanas.
More animations from North Harris College and from LearnersTV.
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Revision materials:
Click4Biology pages: Core & HL
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Here is the top-rated video on the subject on YouTube:




