3.6 Enzymes (inc. AHL 7.6 and C2)
One great enzymatic dollop, for the core content and AHL/ SL Option C. Make sure you use this theory in your write-ups, can relate the action of enzymes to their structure as proteins and look for examples of enzymes in action throughout the course.
Essential Biology 3.6 & 7.6/C2: Enzymes
Check out this article on the potential use of an enzyme in second-generation biofuels.
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Core Resources
- Clear and simple animations, with factors from KScience.co.uk
- More simple animations from John Gianni
- How enzymes work from McGraw Hill
- What is an enzyme? from Northland (the best one – including inhibitors, pathways and feedback inhibition)
- A full collection of savable enzyme animations from Husam Medical
- Enzyme action and the hydrolysis of sucrose from McGraw Hill
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Denaturation:
- Protein denaturation from McGraw Hill
- The pH scale PhET Lab (allow Java to run)
Enzyme activity and kinetics
- Nice virtual lab from KScience.co.uk
- Enzyme kinetics from Wiley Interscience
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Virtual Labs:
- PhET Lab: Reactions and Rates (allow Java)
- Glencoe Biology enzyme activity virtual lab
- Pearson Lab Bench: Enzyme activity
- KScience.co.uk factors affecting rate (scroll down)
Glencoe Bio VirtualLab: pH and substrate concentration vs enzyme activity
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AHL/ Option C Resources
Induced Fit
- Enzyme action and the hydrolysis of sucrose from McGraw Hill
- Induced fit results in a conformational change, by John Gianni
Metabolic Pathways
- Example metabolic pathway, from McGraw Hill
- What is an enzyme? from Northland
- Feedback (end product) inhibition from McGraw Hill
- Simple animation from John Gianni
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Inhibition
- Complete tutorial from Wiley Interscience
- Allosteric enzyme, from John Gianni
- What is an enzyme? from Northland
- Feedback (end product) inhibition from McGraw Hill
Nicholson Pathways Chart, from Sigma Aldrich
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And here’s a quick run down on YouTube:
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If you’re up for some lyrical silliness, here’s an alternate version of the Green Day song, Good Riddance (Time of Your Life):
| Good Riddance (to excess end-products) |
| Pathway’s reached the end point, it’s product overload |
| Negative feedback is the only way to go |
| The allosteric site’s the perfect place to bind |
| To the end product molecules that it can find |
| The change is conformational, the substrate cannot bind |
| Inhibiting the first-step enzyme. |
| With inhibition the end product’s in decline |
| When it drops too low, the cell knows it is time |
| To revert to the original active site |
| I chose this Green Day song ‘cos it’s easy to rhyme |
| The change is quite reversible, inhibitor unbinds |
| Reactivates the first-step enzyme |
| E. coli pumps out tryptophan, butif environment provides |
| It inhibits the first-step enzyme |
| It’s negative feedback control, with allosteric sites |
| Inhibiting the first-step enzyme. |
Here’s the Green Day video:
i-Biology 
nice…new look now!!!!!
Thanks Lawrence – it’s Mystique by WordPress.
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