30-Minute Inquiry: Base-substitution mutations
This has worked well (and been fun) as a topic review, way to make use of databases (ICT in IBBio requirement) and make connections as we.
Question: What do HBB, PAH, PKD1, NF1, CFTR, Opn1Mw and HEXA have in common?
Concepts: Structure vs Function; Universality & Diversity.
- Assign groups by handing out cards with the codes above (we had already studied HBB, so didn’t include it) and asking them to find each other.
- Give them the instructions – to produce a simple poster & 1-minute overview of their disorder, using the guidance in the image below.
- Go. Lots of discussion, lots of questioning. If students get stuck, they need to look it up, evaluate their sources and keep on going.
- Students will need to use the NCBI gene database to get going: http://www.ncbi.nlm.nih.gov/gene
Check they’re on the right track: HBB (sickle cell), PAH (PKU), PKD1 (polycystic kidney disease), NF1 (neurofibromatosis), CFTR (cystic fibrosis), Opn1Mw (medium-wave sensitive colour-blindness), HEXA (Tay-Sachs disease). They are all disorders causes by base-substitution mutations.
After 30 minutes:
- Groups present to the class what they have found.
- As the class sharing continues, ask questions based on connections:
- What similarities and differences do we see?
- What are the normal functions of these genes and how does this connect to our understanding of proteins, channels, pumps, etc.